Risk of COVID-19 complications stratified by SARS-CoV2 Spike Antibody Levels
Applied/Translational Research
Singapore Health Biomedical Congress
National Healthcare Group
31 December 2022
To assess the correlation between SARS-CoV2 spike antibody levels and risk of severe COVID-19 complications. Low anti-spike titres correspond to higher risk of severe COVID-19.
Year Submitted: 2022
Published Date: 31 December 2022
Tags: Applied/Translational Research, Qualitative Research
About this Content
Aims
To assess the correlation between SARS-CoV2 spike antibody levels and risk of severe COVID-19 complications.
Background
COVID-19 vaccination is associated with lower risk of complications. No data correlates antibody levels to severity risk.
Methods
Retrospective cohort study of 298 patients admitted for COVID-19 infection, stratifying severe cases by antibody levels.
Results
Patients with low anti-spike titres (<100 U/ml) had the highest risk of severe COVID-19. Raised serum creatinine, CRP, LDH, and lymphopenia were observed in severe cases.
Conclusion
Low anti-spike titres correspond to higher risk of severe COVID-19. Stratified data supports risk assessment in clinical practice.
Lessons Learnt
Anti-spike antibody titres could be used as a risk assessment tool for severe COVID-19 complications.
Additional Information
SHBC 2022: COVID-19: Our Response to a New Challenge (Poster category) – (Gold Award).
Keywords
Severe COVID-19, SARS-CoV2 Spike Antibody Levels
Innovators' Details
Innovators' Details
Healthcare Cluster(s) | National Healthcare Group |
Organization(s) Involved | Khoo Teck Puat Hospital |
Platform(s) | Singapore Health Biomedical Congress |
Healthcare Professional Group(s) | Medical |
Applicable Specialty or Discipline | Infectious Diseases, Epidemiology, Clinical Research |
Project Lead(s) | Ooi Say Tat |
Project Member(s) | Nyein Chan Maung |
Connect with this contributor!
Nyein Chan Maung - chan.nyein.m@ktph.com.sg