Predicting the pathological complete response (pCR) in breast cancer patients who have undergone neoadjuvant chemotherapy
Care Process & Redesign
Ng Teng Fong Healthcare Innovation Programme
National Healthcare Group
31 December 2023
To explore minimally invasive biopsies to predict pathological complete response (pCR) in breast cancer patients. Non-surgical approaches for pCR show promise but need improved methods and validation.
Year Submitted: 2023
Published Date: 31 December 2023
Tags: Care Process ＆ Redesign, Quality Improvement, Clinical Practice Improvement
About this Content
Aims
To explore minimally invasive biopsies to predict pathological complete response (pCR) in breast cancer patients post-chemotherapy.
Background
Accurate non-invasive pCR prediction could optimize treatment and avoid unnecessary surgeries.
Methods
Studied biopsies, CESM imaging, and pre-operative clinical data for correlations.
Results
51 patients recruited; mammotome biopsies showed partial predictive value for pCR; CESM assessments were subjective.
Conclusion
Non-surgical approaches for pCR show promise but need improved methods and validation.
Lessons Learnt
COVID-19 disrupted recruitment and workflow; more work needed on objective CESM measurement.
Keywords
Predictive Model, Mammography, Chemotherapy.
Innovators' Details
Innovators' Details
Healthcare Cluster(s) | National Healthcare Group |
Organization(s) Involved | Tan Tock Seng Hospital |
Platform(s) | Ng Teng Fong Healthcare Innovation Programme |
Healthcare Professional Group(s) | Allied Health, Medical |
Applicable Specialty or Discipline | Surgery, Diagnostic Radiography |
Project Lead(s) | Patrick Chan Mun Yew |
Project Member(s) | Ern Yu Tan |
Connect with this contributor!
Dr Tan Ern Yu - ern_yu_tan@ttsh.com.sg