Predicting the pathological complete response (pCR) in breast cancer patients who have undergone neoadjuvant chemotherapy
Project Categories
Care Process & Redesign
Platform
Ng Teng Fong Healthcare Innovation Programme
Cluster
National Healthcare Group
31 December 2023
To explore minimally invasive biopsies to predict pathological complete response (pCR) in breast cancer patients. Non-surgical approaches for pCR show promise but need improved methods and validation.
Year Submitted: 2023
Published Date: 31 December 2023
Tags: Care Process ＆ Redesign, Quality Improvement, Clinical Practice Improvement
About this Content
Aims
To explore minimally invasive biopsies to predict pathological complete response (pCR) in breast cancer patients post-chemotherapy.
Background
Accurate non-invasive pCR prediction could optimize treatment and avoid unnecessary surgeries.
Methods
Studied biopsies, CESM imaging, and pre-operative clinical data for correlations.
Results
51 patients recruited; mammotome biopsies showed partial predictive value for pCR; CESM assessments were subjective.
Conclusion
Non-surgical approaches for pCR show promise but need improved methods and validation.
Lessons Learnt
COVID-19 disrupted recruitment and workflow; more work needed on objective CESM measurement.
Keywords
Predictive Model, Mammography, Chemotherapy.
Innovators' Details
Innovators' Details
Healthcare Cluster(s) | National Healthcare Group |
Organization(s) Involved | Tan Tock Seng Hospital |
Platform(s) | Ng Teng Fong Healthcare Innovation Programme |
Healthcare Professional Group(s) | Allied Health, Medical |
Applicable Specialty or Discipline | Surgery, Diagnostic Radiography |
Project Lead(s) | Patrick Chan Mun Yew |
Project Member(s) | Ern Yu Tan |
Connect with this contributor!
Dr Tan Ern Yu - ern_yu_tan@ttsh.com.sg