Association Between Long Term Use of Sodium-glucose Co-transporter-2 (SGLT2) Inhibitors and Cognitive Function in a Longitudinal study
Applied/Translational Research
Care Continuum
National Healthcare Innovation and Productivity Medals
National Healthcare Group
31 December 2021
Explore the longitudinal association between sodium-glucose co-transporter-2 inhibitors (SGLT2i) use and cognitive function. Findings reveal potential neuro-protective benefits of SGLT2i, paving the way for future studies on cognitive decline in T2DM.
Year Submitted: 2021
Published Date: 31 December 2021
Tags: Applied/Translational Research, Care Continuum, Quantitative Research, Chronic Care, Population Health
About this Content
Aims
Explore the longitudinal association between sodium-glucose co-transporter-2 inhibitors (SGLT2i) use and cognitive function in Type 2 diabetes mellitus (T2DM) patients.
Background
SGLT2i reduces cardiovascular and renal risks and shows neuro-protective effects in preclinical studies, but evidence in humans is limited.
Methods
Prospective study with 428 T2DM patients; cognition assessed via RBANS, with linear regression adjusting for demographics, education, and clinical covariates.
Results
≥5 years of SGLT2i use associated with significant improvements in immediate memory and language domains in cognitive assessments.
Conclusion
Findings reveal potential neuro-protective benefits of SGLT2i, paving the way for future studies on cognitive decline in T2DM.
Lessons Learnt
SGLT2i may ameliorate T2DM-induced cognitive decline; consistent long-term use is essential for significant benefits.
Additional Information
Gold award (SHBC Best Poster Award - Clinical Research) at SHBC 2021. Recognized for significant contributions to applied research.
Keywords
SGLT2i, Cognitive Function, Type 2 Diabetes Mellitus
Innovators' Details
Innovators' Details
Healthcare Cluster(s) | National Healthcare Group |
Organization(s) Involved | Khoo Teck Puat Hospital, Admiralty Medical Centre, National Healthcare Group Polyclinics |
Platform(s) | National Healthcare Innovation and Productivity Medals |
Healthcare Professional Group(s) | Medical |
Applicable Specialty or Discipline | Geriatric Medicine, Clinical Research, Endocrinology |
Project Lead(s) | Serena Low |
Project Member(s) | Lim Su Chi |
Connect with this contributor!
Dr. Serena Low - low.serena.km@ktph.com.sg
Project Attachment
C399_KTPH_AMC_NHGP_SHBC_2021_Association_between_long_term_use_of_SGLT2.pdf